Genetic deficiency of thyroxin-binding protein in 4 members of a family
Levrat, R.; Dano, P.; Joliot, A.Y.; Dechaud, H.; Durand, D.V.
La Nouvelle Presse Medicale 9(38): 2811-2813
1980
ISSN/ISBN: 0301-1518 PMID: 6160453 Document Number: 158065
Four members of the same family (2 male and 2 female) with normal thyroid function were found to have decreased total T3 and total T4, elevated response to the T3 test and low free thyroxin index. Such biological changes result from a deficiency in carrier protein and should be distinguished from nearly similar abnormalities observed in low T3 syndrome and hypothyroidism. Whilst gonosomal transmission through the X chromosome of thyroxin-binding protein deficiency seems well established, our findings show that another mechanism, i.e. dominant autosomal heredity, is practically certain.