Fluorouracil, mitomycin-C and adriamycin in the treatment of metastasizing gastrointestinal adenocarcinomas
Späti, B.; Jungi, W.F.; Mayr, A.C.; Hammer, B.; Senn, H.J.
Schweizerische Medizinische Wochenschrift 110(27-28): 1076-1078
1980
ISSN/ISBN: 0036-7672 PMID: 7423154 Document Number: 158062
28 patients with advanced adenocarcinomas were treated with combinations of 5-fluorouracil and mitomycin-C (FM, 21 patients) or of 5-fluorouracil, adriamycin and mitomycin-C (FAM, 7 patients). 5 patients responded, 3 showing an objective response of more than 50% lasting 3-5 months. Toxicity was primarily hematologic, chiefly comprising severe thrombopenias. The results indicate that with these combinations a limited palliative effect can be achieved in only a few patients.