Endogenous serum testosterone in males after different doses and routes of administration of medroxyprogesterone acetate
Novak, E.; Hendrix, J.W.; Seckman, C.E.; Kaiser, D.G.; Stoll, R.G.
Journal of Reproductive Medicine 25(4): 157-160
1980
ISSN/ISBN: 0024-7758 PMID: 7431362 Document Number: 156979
The effects of different doses and routes of administration (both oral and intramuscular) of medroxyprogesterone acetate on endogenous testosterone secretions were studied in healthy male volunteers. There were 3 treatment groups. Serum testosterone levels, measured by radioimmunoassay before, during, and after different doses of medroxyprogesterone acetate, were significantly lowered (P0.05) in these subjects. A tendency to return toward pretreatment values was noted within 3-6 weeks after the last dose of medroxyprogesterone acetate. Testosterone levels were suppressed for the longest period of time through intramuscular administration. No indication of drug-induced toxicity, as judged by vital signs, systemic side effects, standard laboratory evaluations and some special clinical evaluations, was found during treatment or in the period immediately following therapy. No serious or untoward side effects were encountered.