Immunological classification of acute lymphoblastic leukemias
Tubiana, N.; Derre, M.; Carcassonne, Y.
La Semaine des Hopitaux Organe Fonde Par l'Association d'Enseignement Medical des Hopitaux de Paris 56(47-68): 1993-1997
1980
ISSN/ISBN: 0037-1777 PMID: 6256912 Document Number: 156210
Immunological markers in acute lymphoid leukemia complete the cytological study and allow a new classification. 44 cases of acute lymphoïd leukemia were investigated for the presence of T and B membrane markers on bone marrow and/or peripheral blood lymphoblasts. 20 per cent of cases had T lymphoblasts: 10-90 per cent of the lymphoblastic cells exhibited T cells markers (E-Rosetting). 10 per cent of cases had B lymphoblasts: these cells have shown monoclonal surface immunoglobulin. 70 per cent of cases had "non T, non B" lymphoblasts: some of these lymphoblasts formed EAC-Rosettes. These techniques of lymphocytes studies are fruitful in furthering understanding of the structure function relationship of these cells.