Apomorphine-induced stereotypy in mature and senescent rats following cessation of chronic haloperidol treatment
Roffman, M.; Cordasco, F.; Kling, A.
Communications in Psychopharmacology 4(4): 283-286
1980
ISSN/ISBN: 0145-5699 PMID: 7196824 Document Number: 155413
After chronic haloperidol treatment, senescent rats exhibited significantly more apomorphine-induced stereotypy than did similar rats chronically treated with saline. The intensity of this stereotypy was less than that exhibited by mature rats that were chronically treated with haloperidol. Senescent rats chronically treated with saline exhibited less apomorphine-induced stereotypy than mature rats comparably treated. After chronic haloperidol, the percent change in stereotypy from respective control was greater for the senescent rats than the mature rats. Senescent rats apparently were more sensitive to the effects of chronic antipsychotic treatment than mature rats. The data support clinical observations of increased sensitivity of tardive dyskinesia in elderly patients.