Myocardial depressant fraction in the venom of Dendroaspis angusticeps
Wangai, J.; Ng'ang'a, J.N.; Mungai, S.; Thairu, K.; Telang, B.V.
Indian Journal of Physiology and Pharmacology 24(1): 61-64
1980
ISSN/ISBN: 0019-5499 PMID: 7364462 Document Number: 154975
Whole venom Dendroaspis angusticeps produced a negative chronotropic and ionotropic effect on the heart. Isolation of the fraction (T39) produced the same effect. Negative inotropic effect was blocked by atropine. The bradycardia may be due to a cholinergic effect and the negative ionotropic to a direct depressant effect on the myocardium.
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