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Changes in plasma renin activity induced by acute administration of nifedipine in hypertensive patients

Bonaduce, D.; Spirito, G.; Petretta, M.; Romano, E.; Postiglione, M.; Ferrara, N.; Rengo, F.

Giornale Italiano di Cardiologia 9(12): 1452-1455

1979

ISSN/ISBN: 0046-5968
PMID: 398813
Document Number: 153692
In the present study we assessed plasma renin activity (PRA) variations induced by Ca++ antagonist antihypertensive drug Nifedipine in 8 normoreninaemic or hyporeninaemic hypertensive patients. On two successive days three venous blood samples were sampled, two in clinostatic position and the last one 120 min later in orthostatic position; on the second day 20 mg of nifedipine were administered sublingually. Nifedipine increases significantly PRA after orthostatic position compared with starting conditions (p < 0.01) and compared with the values recorded without the drug at the same times (p < 0.01). Both systolic and diastolic blood pressure decreased 15 and 120 min after nifedipine administration while heart rate increased at the same times. Acute nifedipine administration augments PRA in hypertensive subjects; explanatory hypoteses are proposed.

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