Properties of protamine-heparin complexes
Roszkowska, W.; Worowski, K.
Acta Haematologica Polonica 10(1): 39-46
1979
ISSN/ISBN: 0001-5814 PMID: 155386 Document Number: 152286
Protamine-heparin complexes have a considerable resistance to physical factors of the environment such as a high ion strength and acid or alkaline pH. Free protamine is digested by plasmin giving products with a greatly decreased ability to form complexes with heparin and lower antiheparin action. Bound protamine, on the other hand, is resistant to the action of plasmin as a result of which the enzyme does not release heparin from the complexes.
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