Intravaginal estrogen creams and endometrial cancer: no causal association found
Horwitz, R.I.; Feinstein, A.R.
JAMA 241(12): 1266-1267
1979
ISSN/ISBN: 0098-7484 PMID: 762793 Document Number: 152150
In two case-control studies of estrogens and endometrial cancer, women were asked about previous use of intravaginal estrogen creams. In a set of cases and controls chosen by conventional procedures from a tumor registry, the odds ratio was 0.90. In an alternative set of cases and controls who had all received dilatation and curettage or hysterectomy, the odds ratio was 0.82. Despite the reported relationship between oral estrogens and endometrial cancer and although intravaginal estrogen creams are readily absorbed by the vaginal mucosa, we detect no causal association for their use.