Effects of vas deferens clipping on the testicular function in dog
Dixit, V.P.
Indian Journal of Medical Research 69: 75-82
1979
ISSN/ISBN: 0019-5340 PMID: 429050 Document Number: 151747
The effects of vas deferens clipping were studied on the testes and epididymides of dogs. Seminiferous tubule atrophy, decreased spermatogenesis and Leydig cells were observed after vas deferens clipping. Vas deferens clipping led to degenerative changes in the epididymides. Epididymal epithelium regressed and lumen was devoid of spermatozoa. Decreased concentration of RNA, protein and sialic acid in the testes indicated reduced sperm production. High alkaline phosphatase enzyme activity, cholesterol and lipids in the testes of dog after vas deferens clipping is interpreted as an indirect effect resulting from the damage to the spermatogenic activity. Reduced sialic acid levels in the testes of vas clipped dogs indicated an inhibition of androgen production, which is further reflected in reduced Leydig cells nuclear diameter. Hematological study and liver function tests (including histopathological examination) did not show any adverse effects. Normalcy was restored after 200 days of vas deferens clipping. The seminiferous tubules showed full spermatogenesis.