Top Abstract Purchase Related
Home
>
Node
>
Subnode

Experimental investigations of the renal tolerance of cefazedone

Züllich, B.; Sack, K.

Arzneimittel-Forschung 29(2a): 430-433

1979

ISSN/ISBN: 0004-4172
PMID: 582719
Document Number: 151183
Renal tolerance tests in Wistar rats (n = 40) over 12 days showed that the tubulotoxic threshold dose of the cephalosporin antibiotic (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid acid (cefazedone, Refosporen) is 2000 mg/kg/day when the cell excretion rates in the urine are used as the parameter of toxicity. It is concluded that cefazedone and cefazolin are similar in respect of their nephrotoxicity.

Document emailed within 1 workday
Secure & encrypted payments

Raab, W. 1979: Investigations on the action of cefazedone and gentamicin, alone and combined, on renal enzyme excretion in rats Arzneimittel-Forschung 29(2a): 433-434
Czerny, K.; Mitros, M. 1976: Experimental investigations of the effect of "Piasclédine" pharmacological preparation on primary renal tubules Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 31: 227-230
Bertolini, G.; Naliato, P.; Borghi, C. 1985: Renal tolerance of an incremental dosage regimen of anturan in the aged with altered renal function] Minerva Medica 76(32-33): 1463-1467
Daijoh, K.; Kawamura, J.; Yoshida, O. 1978: Experimental study of calcium metabolism in renal failure. I. Production of renal failure rats as experimental model Nihon Jinzo Gakkai Shi 20(2): 175-182
Dingeldein, E.; Wahlig, H. 1979: Blood levels and tissue concentrations of cefazedone in animals Arzneimittel-Forschung 29(2a): 400-403
Adam, D.; Hofstetter, A.G.; Reichart, B.; Schneider, C.; Wolff, H.; Koch, E. 1979: The diffusion of cefazedone into heart muscle, prostatic and skin tissue and into bile Arzneimittel-Forschung 29(12): 1901-1906
Nikolova, M.; Tsikalova, R.; Nikolov, R.; Taskov, M.; Vlahov, V. 1980: Experimental rheoencephalographic and electroencephalographic investigations on piracetam Methods and Findings in Experimental and Clinical Pharmacology 2(6): 327-333
Almén, T. 1983: Experimental investigations with iohexol and their clinical relevance Acta Radiologica. Supplementum 366: 9-19
Enchev, V.; Radeva, M.; Penkov, A. 1986: Glomerulometric data in experimental toxicological investigations Gegenbaurs Morphologisches Jahrbuch 132(4): 577-582
Esser, W.; Klüken, N.; Strötges, W. 1972: Experimental investigations into percutaneous resorption of phospholipids Arztliche Forschung 26(5): 164-170
Sima, A.; Olsson, Y.; Sourander, P. 1971: Experimental investigations on peripheral nerves in undernutrition Nordisk Medicin 85(15): 480-481
Milart, Z.; Szteyn, S.; Chomiak, M.; Welento, J. 1973: Experimental investigations on the visual centres in the sheep. Ii Journal für Hirnforschung 14(1): 227-232
Mester, U.; Krasemann, C.; Stein, H.J. 1978: Experimental investigations concerning a topical application of sisomicin in the eye Klinische Monatsblatter für Augenheilkunde 173(3): 359-363
Wnukowska, N.; Dzbeńiski, T.H. 2001: Investigations of the development of immunity in the course of experimental murine toxocariasis Wiadomosci Parazytologiczne 47(4): 655-659
Andler, W. 1981: Suprasellar tumors in childhood, clinical and experimental investigations Fortschritte der Medizin 99(5): 157-160
Paulini, K.; Soontag, W. 1979: Experimental investigations on the pathogenesis of achillis tendon rupture Zeitschrift für Orthopadie und ihre Grenzgebiete 117(3): 404-408
Vollmar, F.; Bernstein, K.; Böttger, W.; Sedlarik, K.; Eger, H.; Wilde, J.; Fiehring, H.; Reichelt, D.; Reimann, G.; Schilling, B. 1976: Experimental coronary thrombosis in dogs. Morphologic investigations Zentralblatt für Allgemeine Pathologie U. Pathologische Anatomie 120(4): 284-292
Wang, Z.Y.; Lu, S.Q.; Zhang, Y.Q.; Song, J.L.; Wen, Y.; Gui, S.H. 1986: Investigations on the prevalence, immunodiagnosis and experimental model of giardiasis Chinese Medical Journal 99(12): 961-968
Auvert, J.; Abbou, C.C.; Lavarenne, V. 1982: Renal tumour syndrome: hierarchy of investigations Progress in Clinical and Biological Research 100: 437-438
Eisenberger, F.; Chaussy, C.; Klein, U.; Pfeifer, K.J.; Pielsticker, K.; Rothe, R.; Hammer, C.; Heinze, H.G. 1973: Animal experimental investigations of in situ perfusion and cooling of the kidney Der Urologe. Ausg. a 12(5): 268-273