Influence of pyrazole, an inhibitor of alcohol dehydrogenase on the prenatal toxicity of ethanol in the rat
Varma, P.K.; Persaud, T.V.
Research Communications in Chemical Pathology and Pharmacology 26(1): 65-73
1979
ISSN/ISBN: 0034-5164 PMID: 515510 Document Number: 150400
Pyrazole, a potent inhibitor of alcohol dehydrogenase, induced a high incidence of ocular and urinary bladder anomalies in the offspring of rats following treatment on gestational day 9. A single moderate dose of ethanol potentiated the teratogenic action of pyrazole, but alone did not affect embryonic development.
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