Top Abstract Purchase Related
Home
>
Node
>
Subnode

Influence of a GABA transaminase inhibitor on central nervous system oxygen toxicity

Harel, D.; Raday-Bitterman, N.; Kerem, D.

Aviation Space and Environmental Medicine 49(7): 877-879

1978

ISSN/ISBN: 0095-6562
PMID: 352331
Document Number: 126990
A decrease in brain GABA concentration has been implied as the cause of convulsions induced by hyperbaric oxygen (HOP). We therefore examined the influence of sodium valproate, an anticonvulsant and GABA transaminase inhibitor on HOP-induced convulsions in rats. The mean latency of occurrence of the first electrical discharge in the ECoG and the appearance of the first clinical seizure in awake chronically implanted rats was unchanged by administration of sodium valproate prior to HOP exposure. We conclude that either the sodium valproate inhibition of GABA removal is insufficient to compensate for HOP inhibition of its production, or else that GABA concentration changes are not causally related to HOP-induced seizures.

Document emailed within 1 workday
Secure & encrypted payments

Krishnamurti, S.; Wadhawan, M.L. 1974: Central nervous system toxicity with hyperbaric oxygen: case reports Aerospace Medicine 45(7): 782-784
Whelan, H.T.; Bajic, D.M.; Karlovits, S.M.; Houle, J.M.; Kindwall, E.P. 1998: Use of cytochrome-P450 mono-oxygenase 2 E1 isozyme inhibitors to delay seizures caused by central nervous system oxygen toxicity Aviation Space and Environmental Medicine 69(5): 480-485
Placheta, P.; Singer, E. 1980: Experimental changes of GABA receptor binding in the central nervous system Wiener Klinische Wochenschrift 92(20): 725-729
Abelson, H.T. 1978: Methotrexate and central nervous system toxicity Cancer Treatment Reports 62(12): 1999-2001
Merkel, D.E.; Griffin, N.L.; Kagan-Hallet, K.; Von Hoff, D.D. 1986: Central nervous system toxicity with fludarabine Cancer Treatment Reports 70(12): 1449-1450
Bugera-Piecuch, T.E.; Kosicka, B.; Kittel, M.; Smiałek, M. 1987: GABA synthesis in the central nervous system of rats with extrapyramidal syndrome after acute cobalt acetate poisoning in cerebral ischemia Neuropatologia Polska 25(1): 59-69
Chun, H.G.; Leyland-Jones, B.R.; Caryk, S.M.; Hoth, D.F. 1986: Central nervous system toxicity of fludarabine phosphate Cancer Treatment Reports 70(10): 1225-1228
Schnuch, A. 1987: Gyrase inhibitor: central nervous system side effects Deutsche Medizinische Wochenschrift 112(14): 569
Arieli, R.; Gutterman, A. 1997: Recovery time constant in central nervous system O2 toxicity in the rat European Journal of Applied Physiology and Occupational Physiology 75(2): 182-187
Silber, S.J.; Thompson, N. 1972: Mannitol induced central nervous system toxicity in renal failure Investigative Urology 9(4): 310-312
Liuzzi, G.M.; Ventola, A.; Rizzo, T.; Riccio, P.; Quagliariello, E. 1991: Zinc as an inhibitor of myelin basic protein proteolytic breakdown in the central nervous system Acta Neurologica 13(2): 153-161
Mourek, J.; Loutocká, N. 1972: Effect of ouabain on the oxygen consumption by the central nervous system of the rat in the course of postnatal development Sbornik Lekarsky 74(4): 119-124
Ritter, J.; Wenk, H. 1974: Chemodifferentiation of the GABA-transaminase-SSA-dehydrogenase system of the olfactory blub, hippocampus and cerebellum during postnatal development of the albino rat Zeitschrift für Mikroskopisch-Anatomische Forschung 88(5): 923-936
Valadão, J.; Pearl, J.; Verma, S.; Helms, A.; Whelan, H. 2014: Hyperbaric oxygen treatment for post-radiation central nervous system injury: a retrospective case series Undersea and Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society Inc 41(2): 87-96
Leonov, A.N.; Akulenko, M.E. 1973: High-energy phosphate compounds in the central nervous system in acute blood loss and in hyperbaric oxygen therapy Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 17(5): 50-54
Winkelmann, E.; David, E.; Marx, I.; David, H. 1972: Ultrastructural studies on changes in the synaptic structure and perikaryon of the central nervous system in the guinea pig (Cavia porcellus L.) during oxygen deficiency Zeitschrift für Mikroskopisch-Anatomische Forschung 86(2): 157-176
Brown, S.A.; Hall, E.D. 1992: Role of oxygen-derived free radicals in the pathogenesis of shock and trauma, with focus on central nervous system injuries Journal of the American Veterinary Medical Association 200(12): 1849-1859
Janssen, H.F.; Lutherer, L.O. 1983: Influence of central nervous system on arterial pressure during endotoxin shock American Journal of Physiology 244(2): H178-H185
Tumanov, V.P. 1976: A change in the dendrite apparatus of the central nervous system under the influence of several extreme factors Arkhiv Patologii 38(3): 41-47
Schunior, A.; Zengel, A.E.; Mullenix, P.J.; Tarbell, N.J.; Howes, A.; Tassinari, M.S. 1990: An animal model to study toxicity of central nervous system therapy for childhood acute lymphoblastic leukemia: effects on growth and craniofacial proportion Cancer Research 50(20): 6455-6460