Stasis dermatitis as a complication of amlodipine therapy
Gosnell, A.L.; Nedorost, S.T.
Journal of Drugs in Dermatology Jdd 8(2): 135-137
2009
ISSN/ISBN: 1545-9616 PMID: 19213228 Document Number: 15013
Lower leg edema is a common side effect of amlodipine therapy, but is often unrecognized as a contributor to stasis dermatitis. To determine whether amlodipine therapy is more common among patients with stasis dermatitis than age-matched controls. In this retrospective chart review study, the medication lists of all subjects with stasis dermatitis from a single practice site over the past 2 years were compared to alphabetically consecutive charts of patients with basal cell carcinoma to determine the relative usage of amlodipine. Patients with stasis dermatitis (n=43) are more likely to take amlodipine than are basal cell carcinoma patients (n=117) of similar age (19% vs. 5%, P<.02), even when controlled for the use of any antihypertensive medications (25% vs. 10%, P=.05). Amlodipine therapy is associated with stasis dermatitis and discontinuing amlodipine should be considered when stasis dermatitis is diagnosed.
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