Effects of intravenous injection of leukocytic endogenous mediator on cardiohepatic functions in rhesus macaques
Liu, C.T.; Sanders, R.P.; Hadick, C.L.; Sobocinski, P.Z.
American Journal of Veterinary Research 40(7): 1035-1039
1979
ISSN/ISBN: 0002-9645 PMID: 116575 Document Number: 150003
A crude preparation of leukocytic endogenous mediator administered IV over a 10-minute period into a rhesus macaque at a dosage of 10 ml/kg of body weight resulted in hypotension, tachycardia, vasodilation, hypoalbuminemia, and hypoproteinemia. Decreases in cardiac and hepatic functions and biphasic changes in peripheral polymorphonuclear leukocytes also were seen. All measured changes, except hepatic functions and plasma albumin values, returned to base-line values within 24 hours. Data indicate that presently utilized crude leucocytic endogenous mediator preparations contain a heretofore undescribed, and as yet unidentified, component. Induced early cardiovascular changes may be related in part to certain compounds likely to be in the crude preparation.