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Effect of adenosine on phosphofructokinase and phosphoglycerate kinase of rat liver

Lavoinne, A.; Marchand, J.C.; Chedeville, A.; Matray, F.

Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 173(1): 122-126

1979

ISSN/ISBN: 0037-9026
PMID: 158406
Document Number: 149788
Effects of adenosine on purified rat liver phosphofructokinase and phosphoglycerate kinase activity were investigated in vitro. Stimulation by adenosine of the phosphofructokinase has been observed at low concentrations, but the activity was markedly inhibited at high concentrations. Adenosine was an inhibitor of the phosphoglycerate kinase : Lineweaver-Burk analysis indicated that adenosine inhibition was competitive with ATP and non competitive with 3-phosphoglycerate. An interpretation of these results is proposed.

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