Serum cardiac troponin-T as a prognostic marker in septic shock
Choon-ngarm, T.; Partpisanu, P.
Journal of the Medical Association of Thailand 91(12): 1818-1821
2008
ISSN/ISBN: 0125-2208 PMID: 19133515 Document Number: 14869
Cardiac troponins are markers for myocardial injury. Sepsis and septic shock can cause myocardial injury. The significance of elevated cardiac troponin T (cTnT) in septic shock was evaluated in the present study. Serum levels of cTnT were measured in 40 patients with septic shock from Rajavithi Hospital during a nine-month period between December 2004 and August 2005. Patients with acute myocardial infarction were excluded by clinical presentation, electrocardiography, and measurement of creatine kinase. The levels of cardiac troponin T were elevated in 17 patients (42.5%) and not elevated in 23 patients (57.5%). There were 28 deaths (70%) and 12 patients (30%) survived and were discharged from the hospital. cTnT-positive patients had a significantly higher mortality rate (I 7 of 17 patients in the cTnT-positive group and 11 of 23 patients in the cTnT-negative group; p<0.001). Elevated cTnT levels may be a marker for severity of illness and higher mortality in patients with septic shock.
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