Immunocytologic analysis, in rat hypothalamus, of neurons producing peptides related to endorphin, ACTH, MSH and beta-LPH. Comparison with other peptidergic and monoaminergic neurons
Bloch, B.; Lenys, D.; Gouget, A.; Fellmann, D.; Bugnon, C.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 173(4): 719-724
1979
ISSN/ISBN: 0037-9026 PMID: 230887 Document Number: 147690
In rat hypothalamus intraventricularly injected with colchicine, the same neurons of the ventral region are stained with I.S. against alpha and beta-endorphin, (1-24) and (17-39) ACTH, alpha and beta-MSH, and beta-LPH. They are distinct from those producing LH-RH, somatostatin, neurophysin, and dopamine. These results suggest that the same neurons elaborate peptides identical with or immunologically related to endorphins, ACTH, alpha-MSH and beta-LPH, probably issued from a common precursor.