Autoimmunological receptor diseases
Fontana, A.
Schweizerische Medizinische Wochenschrift 109(10): 353-358
1979
ISSN/ISBN: 0036-7672 PMID: 581799 Document Number: 147644
Specific chemical signals are recognized by cell receptors which initiate an appropriate biologic response. Autoimmune reactions against hormone receptors can lead to failure of receptor function. Several mechanisms are responsible for either abnormal stimulation or blockade of the receptor-mediated intracellular events. Immunoglobulins which compete with hormone binding to receptors have been found in Graves' disease, in myasthenia gravis, in acanthosis nigricans with insulin resistance, and in a seizure disorder with primary IgA deficiency.