Mechanisms of detecting organic cholephilic anions in man: comparative studies on plasma depuration of rifamycin-SV. Interference of nicotinic acid and phenobarbital
Gentile, S.; Porcellini, M.; Foglia, F.; Coltorti, M.
Bollettino della Societa Italiana di Biologia Sperimentale 55(13): 1307-1311
1979
ISSN/ISBN: 0037-8771 PMID: 508427 Document Number: 147486
We have studied plasmatic half-life of R-SV administered alone and in association with nicotinic acid, before and after treatment with phenobarbital, in 10 normobilirubinaemic subjects and in 10 patients Gilbert's syndrome, used like controls. Ouer results confirm the existence of some alterations of drug-metabolism produced by associated administration of other drugs, in both healthy and hyperbilirubinaemic subjects, and in these one even more.