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Comparison of the metabolism of 2,4-toluenediamine in rats and mice

Grantham, P.H.; Mohan, L.; Benjamin, T.; Roller, P.P.; Miller, J.R.; Weisburger, E.K.

Journal of Environmental Pathology and Toxicology 3(1-2): 149-166

1979

ISSN/ISBN: 0146-4779
PMID: 547012
Document Number: 147070
The excretion, distribution, and metabolism of 2,4-toluenediamine (TDA) have been compared in rats and mice. The elimination of TDA metabolites into urine was faster and more complete in mice than in rats. However, the feces of rats accounted for a greater percentage of the dose in rats than in mice. The distribution of metabolites in tissues were considerably lower in mice than in rats. The major urinary metabolites observed in the rat were 4-acetylamino-2-aminotoluene, 2,4-diacetylaminotoluene, 4-acetylamino-2-aminobenzoic acid. The major metabolites in the mice were 4-acetylamino-2-aminobenzoic acid, 4-acetylamino-2-aminotoluene and 2,4-diacetylaminobenzoic acid.

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