Top Abstract Purchase Related
Home
>
Node
>
Subnode

Studies on disposition and metabolism of tolmetin, a new anti-inflammatory agent, in rats and mice. II. Urinary metabolites

Hashimoto, M.; Miyazaki, H.; Nambu, K.; Fujii, T.; Arakawa, S.; Yoshida, K.; Utsui, Y.

Drug Metabolism and Disposition the Biological Fate of Chemicals 7(1): 20-23

1979

ISSN/ISBN: 0090-9556
PMID: 35321
Document Number: 146129
A new urinary metabolite of tolmetin was found in rat urine and identified as the hydroxymethyl metabolite (tolmetin-OH), an intermediate in the formation of the known carboxy metabolite (tolmetin-COOH). In rats of two strains, the following percentages of the urinary reactivity of [14Ia1tolmetin were found in 24 hr: unchanged tolmetin-COOH (58--60%), tolmetin-OH (18--24 %), and its conjugate 6--14%. Mouse urine contained the unchanged drug (about 20%), its conjugate and tolmetin-COOH (60%). Similarly to mouse urine, human urine contained negligible amounts of tolmetin-OH.

Document emailed within 1 workday
Secure & encrypted payments

Hashimoto, M.; Miyazaki, H.; Fujii, T.; Nambu, K.; Tanaka, K. 1979: Studies on disposition and metabolism of tolmetin, a new anti-inflammatory agent, in rats and mice. I. Absorption, distribution, and excrection of [14C]tolmetin radioactivity Drug Metabolism and Disposition: the Biological Fate of Chemicals 7(1): 14-19
Mays, D.C.; Hecht, S.G.; Unger, S.E.; Pacula, C.M.; Climie, J.M.; Sharp, D.E.; Gerber, N. 1987: Disposition of 8-methoxypsoralen in the rat. Induction of metabolism in vivo and in vitro and identification of urinary metabolites by thermospray mass spectrometry Drug Metabolism and Disposition: the Biological Fate of Chemicals 15(3): 318-328
Kobayashi, S.; Sakai, T.; Dalrymple, P.D.; Wood, S.G.; Chasseaud, L.F. 1993: Disposition of the novel anticancer agent vinorelbine ditartrate following intravenous administration in mice, rats and dogs Arzneimittel-Forschung 43(12): 1367-1377
Emary, W.B.; Toren, P.C.; Mathews, B.; Huh, K. 1998: Disposition and metabolism of rifapentine, a rifamycin antibiotic, in mice, rats, and monkeys Drug Metabolism and Disposition: the Biological Fate of Chemicals 26(8): 725-731
Kawai, K.; Kawasaki-Tokui, Y.; Odaka, T.; Tsuruta, F.; Kazui, M.; Iwabuchi, H.; Nakamura, T.; Kinoshita, T.; Ikeda, T.; Yoshioka, T.; Komai, T.; Nakamura, K. 1997: Disposition and metabolism of the new oral antidiabetic drug troglitazone in rats, mice and dogs Arzneimittel-Forschung 47(4): 356-368
Kabuto, S.; Kimata, H.; Yonemitsu, M.; Koide, T.; Nakao, H.; Suzuki, J. 1985: Pharmacokinetics of the new antihypertensive agent nipradilol in rats. 1st communication: Metabolism and disposition after single oral administration of [14C]nipradilol Arzneimittel-Forschung 35(11): 1674-1679
Nagaoka, I.; Ishibashi, Y.; Yamashita, T. 1987: Studies on phytohemagglutinin-induced peritonitis of mice: dynamics of inflammatory responses and influence of anticomplementary agents and anti-inflammatory drugs International Journal of Tissue Reactions 9(3): 179-188
Gruber, C.; Guzzon, V.; Ferrero, E. 1976: Parsalmide: a new anti-inflammatory agent. VII. Toxicological studies on tolerance in the rat Bollettino Chimico Farmaceutico 115(2): 195-208
Fennell, T.R.; Miller, J.A.; Miller, E.C. 1984: Characterization of the biliary and urinary glutathione and N-acetylcysteine metabolites of the hepatic carcinogen 1'-hydroxysafrole and its 1'-oxo metabolite in rats and mice Cancer Research 44(8): 3231-3240
Nakamura, H.; Kadokawa, T.; Nakatsuji, K.; Nakamura, K. 1970: Pharmacological studies of a new anti-inflammatory drug, 1-phenylsulfonyl-5,5-diphenylhydantoin (PC-796) in experimental animals. I. Anti-inflammatory, analgesic and anti-pyretic activity Arzneimittel-Forschung 20(8): 1032-1046
Mizojiri, K.; Okabe, H.; Sugeno, K.; Esumi, Y.; Takaichi, M.; Okamura, Y.; Kashiwazaki, K.; Takahashi, N. 1997: Studies on the metabolism and disposition of the new retinoid 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]benzoic acid. 5th communication: factors affecting percutaneous absorption in rats Arzneimittel-Forschung 47(3): 270-275
Petersen, D.R.; Norris, K.J.; Thompson, J.A. 1984: A comparative study of the disposition of nicotine and its metabolites in three inbred strains of mice Drug Metabolism and Disposition: the Biological Fate of Chemicals 12(6): 725-731
Lumholtz, I.B. 1978: Drug information: current anti-inflammatory agents and weaker-acting analgesics. Therapeutic main group: sulindac (Clinoril), fenoprofen (Fenoprofen), tolmetin (Tolectin), diclofenamid (Voltaren) Sygeplejersken 78(22): 11
Goldaniga, G.C.; Pianezzola, E.; Valzelli, G. 1974: Absorption, excretion and metabolism of a new analgesic and anti-inflammatory drug K 4277 in rats, guinea pigs, rabbits and dogs Arzneimittel-Forschung 24(10): 1603-1606
Leeling, J.L.; Muni, I.A.; Kowalski, T.L.; Johnson, N. 1978: Disposition of radiolabeled benzoquinolizinyl propionanilide hydrochloride in rats and dogs and identification of several of its metabolites Toxicology and Applied Pharmacology 46(1): 77-85
Finiguerra, M.; Conti, P.; Gallone, F.; Ferraris, F. 1986: A new non-steroidal anti-inflammatory agent, nimesulide, in the treatment of inflammatory forms of pneumologic importance La Clinica Terapeutica 117(3): 199-206
Maeshiba, Y.; Kiyota, Y.; Yamashita, K.; Yoshimura, Y.; Motohashi, M.; Tanayama, S. 1997: Disposition of the new antidiabetic agent pioglitazone in rats, dogs, and monkeys Arzneimittel-Forschung 47(1): 29-35
Benakis, A.; Tsoukas, G.; Glasson, B. 1973: Localization of butylmalonic acid-mono-(1,2-diphenylhydrazide)-calcium-14C (bumadizone-calcium), a new anti-inflammatory drug, in rats and mice with whole-body autoradiography. Specific localization in the carragenine-inflamed paw and in general experimental polyarthritic rats Arzneimittel-Forschung 23(9): 1231-1236
Hall, I.H.; Oswald, C.B.; Wyrick, S.D.; Maguire, J.H.; Shrewsbury, R.P. 1989: Disposition of the hypolipidaemic agent, 2,3-dihydrophthalazine-1,4-dione, in Sprague Dawley rats Journal of Pharmacy and Pharmacology 41(6): 394-397
De Arcangelis, A. 1971: On the use in anti-rheumatic therapy of a new non-steroid anti-inflammatory agent: glucosamide of monohydrated (N-p-chloro-benzoyl-2-methyl-5-methoxy)-indol-3-acetic acid La Clinica Terapeutica 59(3): 229-239