Mannosidosis of Angus calves
Leipold, H.W.; Smith, J.E.; Jolly, R.D.; Eldridge, F.E.
Journal of the American Veterinary Medical Association 175(5): 457-459
1979
ISSN/ISBN: 0003-1488 PMID: 500478 Document Number: 146996
Mannosidosis, an inherited lysosomal storage disease, was diagnosed in two purebred Angus calves in the USA. Calf 1 was 5 months old and calf 2 was 7 months old when they were examined PM. Both calves had a history of progressive incoordination and ataxia. Gross findings included moderate hydrocephalus. Histological examination revealed intracytoplasmic vacuolation of neurons throughout spinal cord and brain as well as in exocrine pancreatic cells, reticuloendothelial cells of the liver, and medullary sinusoids of lymph nodes. Biochemical study of 61 blood samples from the first calf's herd revealed bimodal distribution of enzyme activity for mannosidase. Two populations could be distinguished in that herd, those with normal mannosidase activity and those heterozygous for the disease.