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A monoclonal antibody to viral glycoprotein blocks virus-immune effector T cells operating at H-2Dd but not at H-2Kd1

Frankel, M.E.; Effros, R.B.; Doherty, P.C.; Gerhard, W.U.

Journal of Immunology 123(5): 2438-2440

1979

ISSN/ISBN: 0022-1767
PMID: 314963
Document Number: 146919
A particular monoclonal antibody that binds to the influenza virus HA molecule inhibits HA-specific thymus-derived lymphocytes mediating cytotoxicity in the context of H-2Dd but not of H-2Kd. Another monoclonal antibody blocks both sets of HA-specific effector T cells. This observation, together with related findings from other laboratories, is considered to support the idea that T cell recognition is directed against some association of viral and H-2 glycoproteins, as proposed in the original formulation of the "altered self" concept.

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van der Heijden, R.W.; Bunschoten, H.; Pascual, V.; Uytdehaag, F.G.; Osterhaus, D.M.; Capra, J.D. 1990: Nucleotide sequence of a human monoclonal anti-idiotypic antibody specific for a rabies virus-neutralizing monoclonal idiotypic antibody reveals extensive somatic variability suggestive of an antigen-driven immune response Journal of Immunology 144(7): 2835-2839
Hancock, W.W.; Sablinski, T.; Milford, E.L.; Tilney, N.L.; Atkins, R.C.; Kupiec-Weglinski, J.W. 1990: Beneficial effects of monoclonal antibody targeting of CD4+ cells during the sensitisation but not effector phase of accelerated rejection of rat cardiac allografts Transplantation Proceedings 22(5): 2115-2116
Parrillo, J.E.; Fauci, A.S. 1978: Comparison of the effector cells in human spontaneous cellular cytotoxicity and antibody-dependent cellular cytotoxicity: differential sensitivity of effector cells to in vivo and in vitro corticosteroids Scandinavian Journal of Immunology 8(2): 99-107
Larose, Y.; Tackaberry, E.S.; Brodeur, B.R. 1991: Human monoclonal antibodies to cytomegalovirus recognize viral epitopes on the surface of virus-infected cells Human Antibodies and Hybridomas 2(2): 67-73
Masuda, T. 1991: Immunoelectron microscopic localization of herpes simplex virus glycoprotein D in infected culture cells using the indirect peroxidase-labeled antibody method Nippon Ganka Gakkai Zasshi 95(9): 817-828
Johnson, V.G.; Schlom, J.; Paterson, A.J.; Bennett, J.; Magnani, J.L.; Colcher, D. 1986: Analysis of a human tumor-associated glycoprotein (TAG-72) identified by monoclonal antibody B72.3 Cancer Research 46(2): 850-857
Thor, A.; Gorstein, F.; Ohuchi, N.; Szpak, C.A.; Johnston, W.W.; Schlom, J. 1986: Tumor-associated glycoprotein (TAG-72) in ovarian carcinomas defined by monoclonal antibody B72.3 Journal of the National Cancer Institute 76(6): 995-1006
Tada, M.; Hinuma, S.; Abo, T.; Kumagai, K. 1980: Murine antibody-dependent cell-mediated cytotoxicity: failure to detect effector cells equivalent to human K cells Journal of Immunology 124(4): 1929-1936
Tanoue, K.; Yamatoto, N.; Kitagawa, H.; Yamamoto, K.; Suzuki, H.; Yamazaki, H. 1987: Functions of platelet glycoprotein (GP)-Ib determined by a monoclonal anti-GP-Ib antibody, TM60 Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 50(3): 706-711
Chávez-Rueda, K.; Agundis-Mata, C.; Cervera, H.; Zenteno, E.; Muñoz, O.; Blanco, F. 1997: Identification of an idiotype on mouse monoclonal antibody directed to a 35 kDa glycoprotein from Entamoeba histolytica Archives of Medical Research 28(Special Issue): 242-244
Edwards, D.P.; Grzyb, K.T.; Dressler, L.G.; Mansel, R.E.; Zava, D.T.; Sledge, G.W.; McGuire, W.L. 1986: Monoclonal antibody identification and characterization of a Mr 43,000 membrane glycoprotein associated with human breast cancer Cancer Research 46(3): 1306-1317
Nagieva, F.G.; Nikulina, V.G.; Barkova, E.P.; Zubkov, A.V.; Kuz'mina, N.S.; Desiatskova, R.G.; Tkachnko, A.V.; Iunasova, T.N. 2011: Monoclonal antibodies to rubella virus glycoprotein E1 Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 1: 61-67
Chattopadhyay, P.; Kaveri, S.V.; Byars, N.; Starkey, J.; Ferrone, S.; Raychaudhuri, S. 1991: Human high molecular weight-melanoma associated antigen mimicry by an anti-idiotypic antibody: characterization of the immunogenicity and the immune response to the mouse monoclonal antibody IMel-1 Cancer Research 51(22): 6045-6051
Lyon, J.A.; Pratt, J.M.; Travis, R.W.; Doctor, B.P.; Olenick, J.G. 1981: Use of monoclonal antibody to immunochemically characterize variant-specific surface coat glycoprotein from Trypanosoma rhodesiense Journal of Immunology 126(1): 134-137
Ohi, H.; Kobayashi, H.; Terao, T. 1993: A new histologic diagnosis for amniotic fluid embolism by monoclonal antibody TKH-2 that recognizes mucin-type glycoprotein Nihon Sanka Fujinka Gakkai Zasshi 45(5): 464-470
Chen, Y.Y.; Suen, J.L.; Wu, W.M.; Chiang, B.L. 1999: Apoptotic phenomenon of immune effector cells in autoimmune NZB x NZW F1 mice Journal of Microbiology Immunology and Infection 32(2): 83-89
Sissons, J.G.; Cooper, N.R.; Oldstone, M.B. 1979: Alternative complement pathway-mediated lysis of measles virus infected cells: induction by IgG antibody bound to individual viral glycoproteins and comparative efficacy of F(ab')2 and Fab' fragments Journal of Immunology 123(5): 2144-2149
Scornik, J.C.; Cosenza, H. 1974: Antibody-dependent cell-mediated cytotoxicity. III. two functionally different effector cells Journal of Immunology 113(5): 1527-1532
Alber, D.G.; Greensill, J.; Killington, R.A.; Stokes, A. 1995: Role of T-cells, virus neutralising antibodies and complement-mediated antibody lysis in the immune response against equine herpesvirus type-1 (EHV-1) infection of C3H (H-2k) and BALB/c (H-2d) mice Research in veterinary science 59(3): 205-213
Fuson, E.W.; Lamon, E.W. 1977: IgM-induced cell-mediated cytotoxicity with antibody and effector cells of human origin Journal of Immunology 118(5): 1907-1909