Dynamics of the connective tissue changes in rats in the process of tumor formation induced by ethacryl (AKR-15) plastic
Rliseev, V.V.
Voprosy Onkologii 25(6): 65-69
1979
ISSN/ISBN: 0507-3758 PMID: 462876 Document Number: 146622
Morphological studies of the rat connective tissue around the implanted plates, made from a plastic Ethacryl (AKP-15) being employed in orthopedic stomatology, have demonstrated a gradual reduction of the proliferative activity of the connective tissue capsule fibroblasts, followed 6 months later by the appearance of diffuse and then focal proliferates in the internal layer with subsequent development of tumors. A histological assay of the collagen-formation revealed no dystrophic changes in the connective tissue characteristic of other types of blastomogenesis. The pattern of diformazane depositing, when histochemically assaying oxido-reduction enzymes, may evidence the cell damage of the connective tissue capsules around the implant in the first months of the experiment.