Electron microscope study of 1- (2,4-dichlorobenzyl) -1H-indazole-3-carboxylic acid, an exfoliative antispermatogenic agent, in the rat testis
Buthala, D.A.; Lobl, T.J.
Cytobios 25(97): 23-28
1979
ISSN/ISBN: 0011-4529 PMID: 575085 Document Number: 146299
We were interested in discovering whether the antifertility agent, DICA [1-(2,4-dichlorobenzyl)-1-H-indazole-3-carboxylic acid] induced Sertoli cell tight junction damage. Testis were fixed in 1% lanthanum nitrite cacodylate-buffered 2% gluteraldehyde at various times following a single oral 100 mg/kg dose of DICA. In control animals adluminal lanthanum was never seen. At one and ten days following DICA treatment adluminal lanthanum was seen. This suggests that the Sertoli cell tight junctions are more permeable to lanthanum following DICA treatment.