Plasma lipids on chronic uraemic and transplantation patients
Viikari, J.; Forsström, J.
Annals of Clinical Research 11(3): 113-117
1979
ISSN/ISBN: 0003-4762 PMID: 227315 Document Number: 146078
The concentrations of total cholesterol, HDL[high-density lipoprotein]-cholesterol and triglyceride in the plasma in renal (n = 48) patients. In undialyzed uremic patients (mean serum creatinine value 439 .mu.mol/l) the plasma cholesterol was somewhat higher (6.47 mmol/l) than in the control (n = 27) group (5.67 mmol/l). HDL-cholesterol was lower (1.02 mmol/l vs. 1.49 mmol/l) and the triglycerides higher (2.07 mmol/l vs. 1.07 mmol/l) than in the control group. In dialyzed patients the cholesterol level (5.88 mmol/l) was lower but the triglyceride level higher (2.58 mmol/l) than in undialyzed patients. Renal transplantation corrected the lipid variables to a certain degree (plasma cholesterol 5.55 mmol/l, plasma HDL-cholesterol 1.27 mmol/l plasma triglycerides 1.15 mmol/l) but HDL-cholesterol remained still somewhat lower than in the control group. No critical level of renal function at which the changes of lipoprotein metabolism arise, was demonstrated. HCL-cholesterol appears to be already low when the diagnosis of renal insufficiency is made.