Morphological and clinical liver changes after taking oral contraceptives

Mölleken, K.; Stahl, E.; Bretzke, G.

Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 34(2): 79-81

1979


ISSN/ISBN: 0044-2542
PMID: 425584
Document Number: 145248
Liver biopsies of 155 oral contraceptives users (ages 16-45) showed that 106 (68.4%) had histologically observable hepatic damage. Sinusoidal ectasia was observed in 73 cases. 53 women had transaminase levels between 50 and 100 E/1, 34 over 100 E/1; such elevated transaminase levels often indicate lesions of the hepatic parenchyma. In 20 cases evidence of hepatitis was found, but it could not be determined whether it was viral in nature or caused by medication use. 5 cases of intrahepatic cholestasis were observed.

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