The use of 22Na as a tracer for long-term bone mineral turnover studies
Palmer, H.E.; Rieksts, G.A.; Palmer, R.F.; Gillis, M.F.
Aviation Space and Environmental Medicine 50(8): 768-773
1979
ISSN/ISBN: 0095-6562 PMID: 115453 Document Number: 143686
When incorporated into bone during growth from birth to maturity, the bone of rats and dogs becomes uniformly labelled with 22Na which is released through metabolic turnover. The 22Na not incorporated into bone matrix is rapidly excreted within a few days when animals are given large, but nontoxic amounts of NaCl. The 22Na tracer can be used to measure bone mineral loss in animals during space flight and in research on bone disease.
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