The effect of collagenase inhibition on bullous eruption and healing process in epidermolysis bullosa
Coradello, H.; Lubec, G.
Der Hautarzt; Zeitschrift für Dermatologie Venerologie und verwandte Gebiete 30(2): 89-91
1979
ISSN/ISBN: 0017-8470 PMID: 217851 Document Number: 143267
The collagenase inhibiting effect of erythromycin already observed in vitro was demonstrated also after oral administration of the drug in vivo in one child with epidermolysis bullosa letalis and one child with epidermolysis bullosa dystrophica. Despite inhibition of skin collagenase activity during administration of the drug the frequency of bullous eruptions and healing process of affected skin areas remained unchanged. This suggests no direct causal relation existing between skin collagenase activity and epidermolysis bullosa. Whether increased collagenase activity reflects a secondary reaction of the organism cannot be concluded from this study.