Effect of acute ischaemia on active and passive large deformation mechanics of canine carotid arteries
Monos, E.; Kovách, A.G.
Acta Physiologica Academiae Scientiarum Hungaricae 54(1): 23-31
1979
ISSN/ISBN: 0001-6756 PMID: 546047 Document Number: 142927
Large deformation mechanical properties of dog carotid arteries excised following 1 h of ischemia and 1 h of reperfusion were compared to those of contralateral normal arteries in vitro. Vascular smooth muscle was invariably activated by 0.5 .mu.g/ml noradrenaline : 13.2 .+-. 2.0%) as that of normal controls (max.: 5.7 .+-. 1.5%) in the pressure range of 0-220 mm Hg. If the smooth muscle was totally relaxed, there were no differences between the geometric (wall thickness, radius) and mechanical properties (stress, incremental elastic modulus, incremental distensibility, strain-energy density) of the arteries in the 2 series. Increased reactivity of postischemic arteries is not caused by changes in geometric or mechanical properties of their passive wall elements.