Molecular recognition of nucleotides by means of ionic interaction in hydrophobic media
Tabushi, I.; Kobuke, Y.; Imuta, J.
Nucleic Acids Symposium Series 6: S175-S178
1979
ISSN/ISBN: 0261-3166 PMID: 547231 Document Number: 142668
Adenosine phosphates, AMP, ADP and ATP were found to be recognized and extracted from aqueous to an organic phase by the newly prepared lipophilic diammonium salt, N,N'-distearyldiammonium dichloride of 1,4-diazabicyclo [2.2.2] octane 1. ADP and ATP were specifically bound by 1 under the condition of no appreciable binding of AMP. The conventional phase transfer reagent, trioctylmethylammonium chloride 2 was far less effective and lacked selectivity fort the binding of adenosine phosphates. This diammonium salt was used as a specific carrier of ADP in the passive transport through a liquid membrane. A high selectivity was observed in the transport rate of ADP relative to that of AMP.