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Side effects of drug for thromboembolism prophylaxis. Results from the University Women's Clinic Freiburg/Br

Ardelt, W.; Pasold, K.; Hillemanns, H.G.

Fortschritte der Medizin 97(10): 471-474

1979

ISSN/ISBN: 0015-8178
PMID: 422091
Document Number: 142591
It is reported on the side-effects of the antithrombotic prophylaxis in 10611 gynecological operations and caesarean sections at the University Hospital Freiburg/Br. Because of multiple side-effects a risk-free method of antithrombotic prophylaxis does not exist. The main problem in using heparin and oral anticoagulants are the complications caused by bleeding. Two cumarine necroses were observed. Two severe anaphylactoid reactions were seen under dextran prophylaxis resulting in the death of one newborn. Wound healing is delayed under low-dose heparin due to an increase in hematomas. Additionally two fatal pulmonary embolisms were caused by the so-called "rebound effect" after use of low-dose heparin.

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