The effect of unilateral pneumonectomy on in vitro drug metabolism by the contralateral lung of rabbits
Mimnaugh, E.G.; Siddik, Z.H.; Trush, M.A.; Drew, R.; Gram, T.E.
Drug Metabolism and Disposition the Biological Fate of Chemicals 7(4): 208-210
1979
ISSN/ISBN: 0090-9556 PMID: 39721 Document Number: 141817
The effect of unilateral pneumonectomy on the drug-metabolizing capability of the remaining lung of male rabbits was studied 3, 10 and 28 days after surgery. During the period of compensatory lung growth which follows pneumonectomy the contralateral lung had a reduced ability to metabolize some model drug substrates. The activities of 4-chloro-N-methylaniline demethylase, glutathione transferase and 4-aminobenzoate N-acetyltransferase were significantly decreased in pneumonectomized animals relative to sham operated controls at 10 days. By 28 days most of the parameters of drug metabolism returned to control levels. Lung hydroxyproline concentration an index of collagen did not differ in pneumonectomized and control animals at any of the time points. The carcinogen 3-methylcholanthrene failed to induce the pulmonary mono-oxygenase system in pneumonectomized animals. The response of pulmonary drug-metabolizing enzymes to unilateral pneumonectomy in rabbits was temporally and qualitatively similar to the response in rat liver after partial hepatectomy.