Demonstration and partial characterization of 22-nm HBsAg and Dane particles of subtype HBsAg/ady
Hess, G.; Shih, J.W.; Arnold, W.; Gerin, J.L.; zum Büschenfelde, K.H.
Journal of Immunology 123(3): 1189-1194
1979
ISSN/ISBN: 0022-1767 PMID: 89163 Document Number: 141370
The present paper describes the demonstration of d, y, w, and r HBsAg determinants in one serum. It was shown that there are two populations of HBsAg particles: HBsAg/ad and HBsAg/ady. All complete Dane particles were of subtype HBsAg/ady. Further characterization of HBsAg/ady particles did not reveal morphologic differences when they were compared with HBsAg/ad and HBsAg/ay particles. An HBsAg/ady phenotype may be the result of a double infection with hepatitis B viruses or exchanges of DNA sequences that determine HBsAg/ay and HBsAg/ad to form a new genotype.