Segregation of HLA haplotypes in a family with infants having spina bifida
Kulakowski, S.; Delire, M.; De Bruyere, M.
Journal de Genetique Humaine 27(3): 205-219
1979
ISSN/ISBN: 0021-7743 PMID: 395274 Document Number: 141303
The search for HLA association in spina bifida is particularly interesting since this condition can be associated with the effect of the T locus in mice. Gene and haplotype frequencies in 32 unrelated patients suffering from spina bifida were studied. Patients and families were examined clinically and radiologically. A high frequency of spina bifida occulta and other vertebral abnormalities was found suggesting genetic determinism but no evidence of linkage with HLA genes or haplotypes was found.