Regional redistributions of blood under peaking and dropping of fever in rats
Kovalev, O.A.; Sonokin, A.V.; Batiaev, M.A.; Sevenovostokova, V.I.; Shetemetevskaia, S.K.
Biulleten' Eksperimental'noi Biologii i Meditsiny 88(11): 533-535
1979
ISSN/ISBN: 0365-9615 PMID: 540137 Document Number: 140529
Regional redistributions of blood under height and drop of fever-heat were studied in rat experiments. Fever was induced by intravenous administration of leukocytic rabbit pyrogen as well as by intravenous injection of pyrogenal. The former factor produces more rapid and more significant temperature rise than the latter one. In all series of experiments multidimensional statistical analysis allowed one to reveal the effect conducive to a relative decrease in the blood content in the brain, myocardium, lungs, liver and to its increase in some abdominal organs, skin, muscle and bone tissues of the extremities, abdomen and pelvis. At the same time there emerged effects directed to blood redistribution mainly from organs and tissuesof the head, neck and chest to the liver.