Antifungal drug combinations for Cryptococcus neoformans and Prototheca spp
Srimuang, S.; Prariyachatigul, C.; Chaiprasert, A.; Rungsipanuratn, W.; Tanphaichitra, D.
Journal of the Medical Association of Thailand 83(1): 57-60
2000
ISSN/ISBN: 0125-2208 PMID: 10710870 Document Number: 1392
Seventy-one isolates of Cryptococcus neoformans and 5 isolates of Prototheca spp. were tested for in vitro susceptibility against amphotericin B alone and against the combination of amphotericin B with each clinically relevant concentration of flucytosine (5-FC) and rifampin by broth dilution methods. The combinations of amphotericin B and rifampin produced greater effect on reduction of the minimal inhibition concentration (MIC) of amphotericin B than did either drug used individually. Flucytosine combined with amphotericin B produced little or no reduction of the MIC compared with amphotericin B alone.
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