Activating effect of indolylhdrazides on rat brain monamine oxidase
Safrazbekian, R.R.; Sukasian, R.S.; Arzanunts, E.M.
Voprosy Meditsinskoi Khimii 24(5): 640-645
1978
ISSN/ISBN: 0042-8809 PMID: 706259 Document Number: 137959
Effects of hydrazide and isopropyl hydrazide of beta-/2-methyl indolyl-3/propionic acid as well as dihydrazide and isopropyl dihydrazide of alpha-butyl-beta/2-methyl-5-carboxyindolyl-3/propionic acid on activity of monoamine oxidase from rat brain were studied in vivo and in vitro. The effects of the preparations depend on the initial activity of the enzyme, concentrations of the compounds and on the substrate used. Decreased monoamine oxidase activity was the most suitable condition for detection of activating effect of compounds studied.