Trypanosomiasis leads to extensive proliferation of B, T and null cells in spleen and bone marrow
Mayor-Withey, K.S.; Clayton, C.E.; Roelants, G.E.; Askonas, B.A.
Clinical and Experimental Immunology 34(3): 359-363
1978
ISSN/ISBN: 0009-9104 PMID: 311257 Document Number: 137947
Immunofluorescent staining combined with a 3H-thymidine pulse and autoradiography showed activation of B, T and null cells in the spleen and bone marrow of inbred mice infected with Trypanosoma brucei. A transient increase in splenic T cells was followed by dramatic increases in B cells (2.5-fold) and in null cells (35-fold). By day 12, after the first peak of parasitaemia, 11% of B cells, 20% of T cells and 87% of null cells were dividing in the spleen. In the bone marrow, very large blast cells appeared within a week of infection.