Photooptical and ultrastructural changes in the microcirculatory bed of the kidney after functional vasoconstriction
Mel'man, E.P.; Shutkin, B.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 85(6): 746-750
1978
ISSN/ISBN: 0365-9615 PMID: 667350 Document Number: 137880
In experiments on rats it was found that at the early stages (5 to 15 minutes) after vasoconstriction of the kidney caused by adrenaline solution there occurred sharp narrowing of the intraorganic arterial bed lumen, particularly that of the afferent arterioles. Ultrastructural changes in the glomerular renal capillary components observed were morphological expression of the effect of angiospasm and circulatory hypoxia. Residual phenomena of constriction of the renal microcirculatory bed still persisted at later stages--in 3, 7 days. These changes characterized the stage of peculiar mobility and contractile properties of their endothelial cells, caused by spasmogenic disturbances of microcirculation.