Circulating immune complexes in active Behçet's disease
Gupta, R.C.; O'duffy, J.D.; Mcduffie, F.C.; Meurer, M.; Jordon, R.E.
Clinical and Experimental Immunology 34(2): 213-218
1978
ISSN/ISBN: 0009-9104 PMID: 737905 Document Number: 137830
Levels of immune complexes (IC) were determined by the Raji /ml) by the former test and 9 by the latter (7-500 .mu.g equivalent AHG/ml). The presence of IC showed a significant correlation with disease activity score (P = 0.003, Mann-Whitney Rank Sum Test). Abnormal values of IC tended to remain abnormal when sera were retested after 1 yr. There was no correlation between IC and duration of disease or any specific organ involvement. The IC were found predominantly in fractions of about 19S and greater when fractionated by sucrose density gradient or Sephadex column techniques. IC may contribute to the pathophysiology of Behcet's disease.