Effects of Trisetum flavescens on calcium and phosphorus metabolism. Mechanism of its action studied through its interaction with diphosphonate
Ston, J.; Wilczek, H.; Pacovský, V.
Physiologia Bohemoslovaca 27(6): 515-520
1978
ISSN/ISBN: 0369-9463 PMID: 214802 Document Number: 137678
The interaction of vitamin D3 and ethane-1-hydroxy-1,1-diphosphonate [EHDP] suggests that these factors have antagonistic effects on the behavior of Ca and phosphate in bone, blood and kidney. Plasma Ca and phosphate levels and the bone concentration of these minerals were studied in experimental rats simultaneously given EHDP and dried T. flavescens orally. Studies carried out during the past few years indicate that the plant contains a factor with the biological properties of 1,25-dihydroxyvitamin D3. When administered together with EHDP, T. flavescens lowers the blood phosphate level and raises the Ca and phosphate concentration in the bones. The calcinogenic activity of T. flavescens is probably not identical with physiological vitamin D3 [1,25-dihydroxyvitamin D3] activity, although one of its properties is the ability to stimulate intestinal Ca absorption. The positive Ca balance induced by T. flavescens may also be due to inhibition of bone resorption. The calcinogenic principle seems to interfere with Ca-phosphate homeostasis by means of other factors [calcitonin, parahormone].