Transplantable IgD immunoglobulin-secreting tumors in rat
Bazin, H.; Beckers, A.; Urbain-Vansanten, G.; Pauwels, R.; Bruyns, C.; Tilkin, A.F.; Platteau, B.; Urbain, J.
Journal of Immunology 121(5): 2077-2082
1978
ISSN/ISBN: 0022-1767 PMID: 712079 Document Number: 136857
The LOU/C/Wsl rat inbred strain presents a high incidence of spontaneous malignant ileocecal immunocytomas or monoclonal immunoglobulin-secreting tumors. Some tumors have been transplanted in histocompatible animals over years without any change in their secretion products. Among approximately 600 different monoclonal proteins we have studied so far, we recognized six showing properties different from those of rat IgM, IgA, IgE, or IgG classes, and characteristic of the IgD class.