Effect of intragastric bile on canine lower oesophageal sphincter pressure
Laitinen, S.; Mokka, R.E.; Larmi, T.K.
Scandinavian Journal of Gastroenterology 13(3): 369-372
1978
ISSN/ISBN: 0036-5521 PMID: 39331 Document Number: 136732
The effect of intragastric bile on lower esophageal sphincter (LES) pressure was studied in 7 dogs. Five milliliters of fresh canine bile was instilled into the stomach, and its effect on LES pressure and intragastric pH was observed for 1 h. In a control study 5 ml of physiological saline was used instead of bile. Bile instillation led to a statistically significant increase in LES pressure, which reached its maximum in 20 min. LES pressure returned to the resting level in 60 min. Saline instillation produced no significant change in LES pressure. The rise in intragastric pH was slight and equal in both groups. Bile contamination of gastric juice, at least 1 of short duration, apparently does not have any immediate harmful effect on LES competence in the dog.