Pancreatic response to intestinal perfusion with lactic acid or acidified albumin
Solomon, T.E.; Grossman, M.I.; Meyer, J.H.
American Journal of Physiology 235(5): E560-E564
1978
ISSN/ISBN: 0002-9513 PMID: 31795 Document Number: 136435
In 4 dogs with pancreatic fistulae, solutions of lactic acid and acidified bovine serum albumin were perfused at 50 ml/15 min into the intestine to deliver 1, 2 or 4 mmol/15 min of acid titratable to pH 4.50, the threshold pH for bicarbonate stimulation, from an initial pH of 2.00 or 3.50. At both pH 2.00 and 3.50 and at all titratable acid loads, bicarbonate secretory responses to lactic acid and acidified albumin were not different. Equal titratable acid loads of HCl produced greater secretory responses. The results do not suggest that permeability of weak acids across the intestinal mucosa is a factor in their ability to stimulate pancreatic bicarbonate output.