Salicylates and creatinine clearance re-evaluated
Brooks, P.M.; Cossum, P.
Australian and New Zealand Journal of Medicine 8(6): 660-661
1978
ISSN/ISBN: 0004-8291 PMID: 285690 Document Number: 136415
Salicylates increase the serum creatinine and decrease the creatinine clearance in normal volunteers and patients with rheumatoid arthritis and systemic lupus erythematosus. This study suggests that changes in serum creatinine and creatinine clearance are transient when salicylate therapy is commenced in normal volunteers and that these parameters return to normal with continuation of therapy. The creatinine clearance and serum creatinine are still reasonable screening tests for assessing renal function in patients receiving salicylate therapy as long as salicylate therapy has been continued for at least 2 wk. Some compensatory mechanism may occur in renal function and physiology when patients are first put on salicylate therapy reflected by the transient change in the measured parameters.