Role of the bile in lesions of the intestinal mucosa above a mechanical occlusion
Mirkovitch, V.; Robinson, J.W.; Mosimann, F.; Macarone-Palmieri, R.; Blanc, D.
Helvetica Chirurgica Acta 45(1-2): 125-127
1978
ISSN/ISBN: 0018-0181 PMID: 659228 Document Number: 136256
In dogs, the principal lesion in the ileal mucosa above a mechanical obstruction is the induction of a secretory state in which there is a net loss of water and electrolytes into the intestinal lumen. The role of stagnated bile as a possible agent provoking this secretion was explored by ligating the common bile duct and diverting the bile by means of an anastomosis between the gall bladder and the ileum distal to the obstruction. Seven days after creation of an obstruction with bile derivation, the functional and morphological changes in the obstructed loop were almost identical to those occurring in animals with obstructions without bile diversion. The secretory response above the obstruction continued unabated. These results suggest that the secretion in the obstructed intestine is not influeced by the presence of bile.