Note on the design of multi-institution three-treatment studies
Makuch, R.W.; Simon, R.M.
Cancer Clinical Trials 1(4): 301-303
1978
ISSN/ISBN: 0190-1206 PMID: 757147 Document Number: 136221
Attention has recently focused on the appropriate use of statistics for the analysis of end results from clinical trials, with a corresponding lack of emphasis concerning the experimental design of such studies. In this paper, a particular design for a three-treatment multi-institution clinical trial is reviewed due to its recent increase in popularity. Although it may appear desirable at first, further investigation indicates that several difficulties may arise in the subsequent analysis and interpretation of the data. Defects of the design are discussed, and an alternative design is recommended.
Document emailed within 1 workday
Related Documents
Thogersen, O. 1998: A note on intergenerational risk sharing and the design of pay-as-you-go pension programs Journal of Population Economics 11(3): 373-378Aguzzi, P.; Andreoli, F.; Bartolozzi, C.; Bedogni, G.; Bayeli, P.; Cacciamani, G.; Caenazzo, E.; Cammisa, M.; Camposampietro, A.; Canossi, G.; Capurso, L.; Catalano, D.; Colagrande, C.; Cortivo, P.; Crocellà, A.; Daniele, P.; De Nigris, E.; Fargnoli, R.; Farini, R.; Federici, T.; Ferrerri, C.; Fornaciari, M.; Freddara, V.; Frosini, C.; Gabbrielli, L.; Galeazzi, R.; Giani, S.; Gozzi, G.; Graziani, L.; Guercia, C.; Guercia, M.; Koch, M.; Lorenzini, I.; Macchini, M.; Masi, A.; Miceli, F.; Montesi, A.; Muzzio, P.C.; Nicoli, F.; Nieri, G.; Norberto, L.; Pacini, F.; Pagliari, U.; Pucci, F.; Rogo, G.P.; Romagnoli, R.; Sandri, A.; Sogliani-Raschini, C.; Vecchioli, A. 1979: Multi-institution, multidisciplinary radiology and endoscopy trial of the diagnostic accuracy of the double contrast examination of the stomach surface La Radiologia Medica 65(12): 867-872
Voche, P.; Merle, M. 1994: The "star": a design principle of antebrachial radial fasciocutaneous flap. Technical note Annales de Chirurgie Plastique et Esthetique 39(3): 318-320
Jiang, F.-c. 2009: The multi-target drugs and their design Yao Xue Xue Bao 44(3): 282-287
Cristea, A.; Nicolaescu, T.; Copelovici, Y.; Grosser, F.; Cajal, N. 1981: Mathematical studies on the chronicization of viral hepatitis. Note II. Evolution equations of the overall indicators reflecting the state of the infected liver tissue and their use for prognosis and treatment optimization Virologie 32(2): 105-113
Yang, L.; Peng, M.; Rao, L.; Mao, K.; Zheng, C. 2009: Design and development of the multi-dimensional ultrasonic reconstruction and visualization system Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 26(4): 878-882
Guo, X.; Ge, J.; Zhang, Z.; Hong, X. 2001: Design of multi-channel EEG collection system for stereoscopic VEP and study of the VEP evoked by binocular disparity Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 18(3): 362-365
Zhao, X.; Chen, M.; Peng, Y.; Li, Y. 2011: Optimization of the hydrolysis process for C21 steroidal glycoside of bai shou wu by acetic acid with multi-target orthogonal design Zhongguo Zhong Yao Za Zhi 36(5): 569-572
Feige, U.; Polla, B.S. 1994: Hsp70--a multi-gene, multi-structure, multi-function family with potential clinical applications Experientia 50(11-12): 979-986
Mahmood, I.; Mahayni, H. 1999: A limited sampling approach in bioequivalence studies: application to long half-life drugs and replicate design studies International Journal of Clinical Pharmacology and Therapeutics 37(6): 275-281
Raghava, G.P.; Sahni, G. 1994: GMAP: a multi-purpose computer program to aid synthetic gene design, cassette mutagenesis and the introduction of potential restriction sites into DNA sequences Biotechniques 16(6): 1116-1123
Strijdom, H.; De Boever, P.; Walzl, G.; Essop, M.F.; Nawrot, T.S.; Webster, I.; Westcott, C.; Mashele, N.; Everson, F.; Malherbe, S.T.; Stanley, K.; Kessler, H.H.; Stelzl, E.; Goswami, N. 2017: Cardiovascular risk and endothelial function in people living with HIV/AIDS: design of the multi-site, longitudinal EndoAfrica study in the Western Cape Province of South Africa Bmc Infectious Diseases 17(1): 41
Geissbuhler, A.; Spahni, Séphane.; Assimacopoulos, Aé.; Raetzo, M-André.; Gobet, Gérard. 2004: Design of a patient-centered, multi-institutional healthcare information network using peer-to-peer communication in a highly distributed architecture Studies in Health Technology and Informatics 107(Pt 2): 1048-1052
Verougstraete, C.; Libert, J.; Martin, J.J.; Danis, P. 1977: Ocular ultrastructural studies in ceroid lipfuscinosis: preliminary note Bulletin de la Societe Belge d'Ophtalmologie 1977(176): 27-35
Allocca, G.; Tramontana, S.; Chiantera, A. 1971: Histochemical studies of steroidogenesis of the fetal appendages in pregnancy. (Preliminary note) Minerva Ginecologica 23(15): 651-652
Cowan, F.M.; Pascoe, S.J.S.; Langhaug, L.F.; Dirawo, J.; Chidiya, S.; Jaffar, S.; Mbizvo, M.; Stephenson, J.M.; Johnson, A.M.; Power, R.M.; Woelk, G.; Hayes, R.J. 2008: The Regai Dzive Shiri Project: a cluster randomised controlled trial to determine the effectiveness of a multi-component community-based HIV prevention intervention for rural youth in Zimbabwe--study design and baseline results Tropical Medicine and International Health: Tm and Ih 13(10): 1235-1244
Hall, D.J.; Donaldson, R.J. 1980: A note on differences between the work undertaken by area medical officers of single-district and multi-district health authority areas in England and between district community physicians in England who are and who are not 'proper officers' Community Medicine 2(1): 57-62
Umeda, Y.; Imaizumi, M.; Tanaka, T. 2011: Outcome of treatment for chest trauma at a single institution Kyobu Geka. Japanese Journal of Thoracic Surgery 64(7): 545-547
O'Brien, M.F.; Stafford, E.G.; Gardner, M.A.; Pohlner, P.G.; McGiffin, D.C. 1987: A comparison of aortic valve replacement with viable cryopreserved and fresh allograft valves, with a note on chromosomal studies Journal of Thoracic and Cardiovascular Surgery 94(6): 812-823
Cullen, J.W. 1986: Design of cancer prevention studies Cancer Detection and Prevention 9(1-2): 125-138