Effect of glucagon on glomerulopressin production in diabetic dogs
Del Castillo, E.; Fuenzalida, R.; Rapoport, A.L.; Uranga, J.
Acta Physiologica Latino Americana 28(4-5): 179-184
1978
ISSN/ISBN: 0001-6764 PMID: 555836 Document Number: 135828
Glucagon (21.5 +/- 0.23 ng/min/kg) was infused through the portal vein of normal or pancreatectomized dogs. It was observed that a dose of glucagon that produces no significant change in the glycemia of normal dogs has a very small activity in the production of glomerulopressin and does not alter glomerular filtration rate (GRF). In pancreatectomized dogs this same dose of glucagon also does not alter glycemia but it induces a large increase in the production of glomerulopressin and GFR. Our results suggest that in pancreatectomized dogs glomerulopressin production is more sensitive to glucagon infusion than in normal dogs.